Ep. 24: How to Slow Aging Part 2: Problems With Caloric Restriction and What To Do Instead

07 Sep 2020 Ep. 24: How to Slow Aging Part 2: Problems With Caloric Restriction and What To Do Instead

Posted at 10:45h in Podcast by Jay Feldman 0 Comments

Where the calorie restriction research falls short and why eating less is not the answer for slowing aging and extending lifespan
Why eating fewer omega-3s and omega-6s is vital for longevity and anti-aging
Why carb restriction and “fat burning” causes stress that increases aging
How to attain the benefits from carbohydrate restriction while still eating carbs
Why eating more calories can slow aging despite the research in favor of caloric restriction

3:26 – the problems with caloric restriction longevity research

23:12 – excessive levels of physiological stress and the resulting stress hormones cause aging and decrease lifespan

30:56 – carb and calorie restriction cause stress that leads to aging and reduced function, but can still have net benefits

41:08 – reducing omega-6s and omega-3s to slow aging and extend lifespan

Aging, Metabolism, and Caloric Restriction (article)
Life extension in C. elegans longevity research occurs due to a hibernation-type state called dauer which is not representative of a slowing of aging or improvement in health (1)
Hormesis Part 1: Does Stress Make You Stronger? (article)
Hormesis Part 2: Flawed Research and Harmful Misapplications (Including Ketogenic Diets, Intermittent Fasting, Calorie Restriction, and More) (article)
Amino acid restriction (particularly methionine) accounts for the effects of calorie restriction (1, 2, 3, 4)
Glycine protects against the effects of methionine (1, 2, 3, 4, 5, 6)
Methionine restriction lowers membrane unsaturation (1 )
A reduction in endotoxin and shift in gut microbiome accounts for the benefits of calorie restriction (1)
Endotoxin absorbed with saturated fat does not cause the inflammation or symptoms that would be expected (1, 2, 3)
A reduction in yeast ingestion accounts for the effects of calorie restriction in Drosophila (1)
Caloric restriction doesn't lower mass-specific metabolic rate in rats, mice, and Drosophila (1, 2, 3, 4)
Carbs vs. Fats: Hormonal Effects (article)
Gut and Digestion Part 1: Our Gut and Energy Balance (podcast episode)
Gut and Digestion Part 2: Ideal Foods For Our Gut (podcast episode)
Polyunsaturated Fats (PUFA) and Energy Balance (podcast episode)
PUFA breakdown products and various diseases (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)