31 Aug 2020 Ep. 23: How to Slow Aging Part 1: Increasing Your Metabolism And Competing Theories

Posted at 22:48h in Podcast by

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In this episode we discuss:

  • Why increasing our metabolism allows us to age slower and live longer
  • Why PUFA oppose health, shorten lifespan, and drive aging
  • The role of free radicals and oxidative stress in aging
  • Why the current views of aging are incomplete
  • The problems with aging and lifespan research and how this has lead to misguided recommendations

3:24 – the rate of living theory of aging (do you really live fast and die young?)

10:22 – free radical and oxidative stress theories of aging

17:27 – the membrane pacemaker theory of aging

40:54 – the bioenergetic view of aging

46:46 – problems in aging and lifespan research

50:31 – a further explanation of the bioenergetic view of aging

Links from this episode

  • Aging, Metabolism, and Caloric Restriction (article)
  • Refutations of the rate of living theory (1, 2, 3)
  • A higher resting metabolic rate within species is associated with increased longevity and reduced aging, whereas a Refutations of the rate of living theory (1)
  • The membrane pacemaker theory of aging (1, 2)
  • Polyunsaturated Fats (PUFA) and Energy Balance (podcast episode)
  • Arachadonic acid and DHA are 160 and 320 times as susceptible to peroxidation as oleic acid, respectively (1)
  • Energy Is Everything (podcast episode)
  • Mitochondrial function and aging (1, 2, 3, 4, 5)
  • CO2 protects against reactive oxygen species (ROS), reactive nitrogen species (RNS), and lipid peroxidation (1, 2, 3)
  • ATP protects against oxidative stress (1, 2)
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