Ep. 57: Glycolysis, Lactate, and pH balance (Oxygenation, Swelling, and pH Balance Part 2)

Listen to the podcast on Apple Podcasts | Google Podcasts | Stitcher| Spotify

In this episode we discuss:

  • Why lactate is not a harmless byproduct of glycolysis
  • How lactate drives swelling and prevents proper mineral balance, oxygenation, and pH balance
  • Misconceptions around pH balance and the idea that alkalinity is healthy
  • Why we want our cells to be acidic rather than alkaline
  • What we can do to maintain proper pH balance throughout our bodies

3:13 – contrasting complete glucose oxidation with anaerobic and aerobic glycolysis

17:28 - the harmful and degenerative effects of inefficient glucose metabolism and excess lactate production

25:19 – the effect of lactate and inefficient metabolism on swelling, mineral balance, oxygenation, and pH balance

35:35 – whether there’s validity to the acid alkaline ash diet

48:16 – the impact of mitochondrial respiration on pH balance

 51:13 – physiological control of pH balance

Links from this episode

  • Mel
    Posted at 14:38h, 18 May Reply

    This podcast was pretty technical for me but I’m looking forward to part 3! I have polycythemia (high red blood cells, hemoglobin, hematocrit) and doc thinks sleep apnea is causing it. Had cpap for 1-1/2 yrs and numbers still the same. I’d love to know your take on this and what would help. Thanks!

    • Jay Feldman
      Posted at 10:12h, 19 May Reply

      I know it was a bit technical but I hope it was still helpful!

      Sleep apnea could be involved, or any other situation causing hypoxia. In part 4 we’ll discuss things that can help increase CO2 and decrease excess glycolysis/lactate, so those suggestions would be the first place I’d start. I’d look into Buteyko breathing if you haven’t already (this is a good website: https://normalbreathing.com/) and work on sorting out what could be going on metabolically that could be inhibiting efficient glucose oxidation (endotoxin, nutrient deficiencies, PUFA, excess stress, etc.).

  • susan stewart
    Posted at 21:11h, 20 June Reply

    How does this information translate to a measurable parameter, such as urinary pH? I know there is an optimal balance between too acidic and too alkaline. I have generally felt that 6.5 – 7.5 urinary pH is
    generally best (extracellular?). When I started Ray Peat principals (vegetarian version w/eggs, dairy)
    my urine became very acidic unless I used an alkalyzing formula (Calcium gluconate, magnesium bisgylcinate, potassium bicarbonate) to balance. If you don’t measure, how do you know you have optimal cellular/extracellular respiration and metabolism? I am dealing with chronic back pain but other wise stress and toxicity is low and don’t have symptoms that might guide me.

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.