Ep. 77: Why You DON’T Want to Force Autophagy, Mitochondrial Biogenesis, & Uncoupling (Hormesis Part 3)

13 Dec 2021 Ep. 77: Why You DON’T Want to Force Autophagy, Mitochondrial Biogenesis, & Uncoupling (Hormesis Part 3)

Posted at 04:09h in Podcast by Jay Feldman 0 Comments

Why the stress caused by calorie restriction, exercise, cold thermogenesis, fasting, ketogenic diets, Wim Hoff breathing, and supplements like resveratrol is not supportive of our health
Why autophagy, mitochondrial biogenesis, and uncoupling are not always beneficial
Whether being tolerant to stress is a sign of health
Why it’s virtually impossible to apply hormesis in a practical sense
The difference between reactive oxygen species production in a high energy state versus a low energy state

3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis

13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations

28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis

37:05 –the difference between producing ROS in a high energy state versus a low energy state

49:16 – the low energy, high ROS state is a feature of degenerative conditions