
13 Dec 2021 Ep. 77: Why You DON’T Want to Force Autophagy, Mitochondrial Biogenesis, & Uncoupling (Hormesis Part 3)
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In this episode we discuss:
3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis
13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations
28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis
37:05 –the difference between producing ROS in a high energy state versus a low energy state
49:16 – the low energy, high ROS state is a feature of degenerative conditions
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