Ep. 78: Why Maximizing Energy Production and Minimizing Stress Is Optimal For Health (Hormesis Part 4)

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In this episode we discuss:

  • How you can induce mitochondrial biogenesis and uncoupling without stress
  • Why you want tighter mitochondrial coupling if you want to induce uncoupling in a healthy way
  • The difference between reactive oxygen species production in a high energy state versus a low energy state
  • How many supposedly hormetic interventions, like exercise, fasting, and ketogenic diets, can be beneficial despite the stress they cause rather than because of it
  • How the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view
  • What anti-hormesis looks like in a practical sense 

3:22 – the difference between producing ROS in a high energy state compared to a low energy state  

9:38 – how ATP protects against oxidative stress 

21:55 – how CO2 protects against oxidative stress 

26:31 – how tighter mitochondrial coupling is better for inducing uncoupling 

27:48 – the broader context of why we want to adapt to a high-energy, low-stress state  

33:28 – how exercise can be beneficial despite the stress it causes, rather than because of it 

47:06 – how low-carb/ketogenic diets can be beneficial despite the stress they cause, rather than because of it 

57:40 – what to expect when moving away from a hormetic approach 

1:02:16 – how the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view 

1:03:39 – what anti-hormesis looks like in a practical sense 

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