The True Cause of Type 2 Diabetes and Insulin Resistance

studies cited and relevant articles

  • Nicki
    Posted at 08:34h, 22 October Reply

    Hi Jay, I’m a nutritional therapist and have been digging into your work and reading your references. What I’d like some help with is the the following: let’s say that the reason diabetics and pre diabetics are suffering from hyperglycaemia is because the mitochondria are dysfunctional and that this dysfunction is down to a mix of the following: ROS, the xenobiotics in our environment, infection from microbes and endotoxins, and pufas. What I’d like some clarity on is what is the mechanism that is causing the hyperinsulinaemia to fail to switch off the hepatic production of glucose from gluconeogenesis, proteolysis and ketogenesis. The Sonksen and Sonksen article was describing how this is the main function of insulin; to put the brakes on hepatic glucose production. So clearly the insulin is not doing this, hence more insulin is produced by the beta cells in the pancreas. At the top of my question we have a picture of insulin resistance at the level of the mitochondria where the Krebs and the ETC can’t oxidise the glucose. But at the level of the hepatic inhibition of glucose production, what is stopping the insulin from inhibiting that production. I’m not sure the mitochondria would have that role? What does insulin resistance really mean here?

    • Jay Feldman
      Posted at 22:06h, 24 October Reply

      Hi Nicki. Great question! The hyperinsulinemia does actually turn off the hepatic glucose output, but normal amounts of insulin don’t. I would largely blame this on the elevated stress hormones (cortisol, adrenaline, and especially glucagon) that are seen in this state due to the impairment in energy production. Higher amounts of insulin are needed to counteract the gluconeogenic effects of the excessive cortisol/adrenaline/glucagon at the liver.

      We discussed the role of hyperglucagonemia in diabetes/insulin resistance in this podcast episode and will be digging further into insulin resistance in future episodes:

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