Ep. 84: Fructose and Uric Acid: Are David Perlmutter and Rick Johnson Wrong? (Part 1) 

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In this episode we discuss:

  • Whether David Perlmutter and Rick Johnson are right about fructose and uric acid being drivers of poor metabolic health 
  • Why fructose will not cause ATP depletion when it’s consumed in normal contexts 
  • Why fructose and uric acid are not the drivers of metabolic syndrome and degenerative conditions 
  • The protective effects of fructose in the liver 
  • Why it’s extremely  important to consider the different contexts in which uric acid is produced 

3:56 – why we’re discussing fructose and uric acid 

8:38 – the general argument that fructose consumption drives uric acid production and that this is responsible for disease and degeneration 

14:48 – our general counterargument that fructose consumption does not drive disease and degeneration via uric acid production 

18:41 – whether fructose depletes ATP in the liver 

30:03 – fructose is extremely protective and generally increases ATP availability in the liver 

36:27 – how fructose can increase uric acid via ATP depletion 

38:51 – why fructose doesn’t cause ATP depletion and uric acid production unless it’s given in extreme, non-physiologically relevant contexts 

1:04:50 – whether uric acid is the driver of metabolic syndrome and many degenerative conditions by driving oxidative stress 

1:15:46 – why xanthine oxidase is a major confounding variable to consider when evaluating whether uric acid production is harmful 

1:27:02 – whether the activation of AMP deaminase is a reason not to consume fructose 

1:27:55 – average fructose intakes are far below the amounts that are typically used in research 

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