
23 Jun 2022 Ep. 84: Fructose and Uric Acid: Are David Perlmutter and Rick Johnson Wrong? (Part 1)
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In this episode we discuss:
3:56 – why we’re discussing fructose and uric acid
8:38 – the general argument that fructose consumption drives uric acid production and that this is responsible for disease and degeneration
14:48 – our general counterargument that fructose consumption does not drive disease and degeneration via uric acid production
18:41 – whether fructose depletes ATP in the liver
30:03 – fructose is extremely protective and generally increases ATP availability in the liver
36:27 – how fructose can increase uric acid via ATP depletion
38:51 – why fructose doesn’t cause ATP depletion and uric acid production unless it’s given in extreme, non-physiologically relevant contexts
1:04:50 – whether uric acid is the driver of metabolic syndrome and many degenerative conditions by driving oxidative stress
1:15:46 – why xanthine oxidase is a major confounding variable to consider when evaluating whether uric acid production is harmful
1:27:02 – whether the activation of AMP deaminase is a reason not to consume fructose
1:27:55 – average fructose intakes are far below the amounts that are typically used in research
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