Ep. 95: Hypothyroidism In Context & Thyroid Hormone Basics (Hypothyroidism Part 1)

14 Jul 2023 Ep. 95: Hypothyroidism In Context & Thyroid Hormone Basics (Hypothyroidism Part 1)

Posted at 04:45h in Podcast by Jay Feldman 0 Comments

Why hypothyroidism is not the root cause of your issues
Why TSH on its own is not a good marker of thyroid status
The importance of thyroid hormones for sex hormone production, gut health, and immune function
T3’s effects on autophagy, mitochondrial biogenesis, and uncoupling
Whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign

1:19 – an introduction to hypothyroidism and common symptoms of hypothyroidism

9:02 – the broader biological context of hypothyroidism and hypothyroidism as a low metabolic state

12:45 – why hypothyroidism is not the root cause

16:23 – the basics of the different thyroid hormones and their regulation

19:54 – the hypothalamic-pituitary-thyroid axis and the nuances within the negative feedback loops

24:45 – the basics of thyroid hormone production

29:37 – the basics of thyroid hormone conversion

35:17 – the larger context of thyroid hormone production and conversion

38:58 – the basics of thyroid hormone transport

41:44 – the basics of thyroid hormone uptake

46:23 – the nutrients involved in thyroid hormone production and conversion

50:26 – the cellular effects of T3 (metabolic stimulation, uncoupling, autophagy, mitochondrial biogenesis, steroidogenesis from cholesterol)

57:29 – the effects of T3 on gut health, immune function, and aging

1:03:08 – whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign

1:08:41 – the relationship between vitamin A and thyroid hormones

The regulation of TRH and TSH production in the pituitary and hypothalamus is accomplished via independent, local T3 generation (1, 2)
Amount of T3 & T4 production from the thyroid and peripheral tissues (1, 2)
T3 and T4 require active, energy-dependent transport with T4 transport requiring more ATP than T3 transport (1)
T3 increases ATP production while decreasing oxidative stress (1)
T3 activates uncoupling, autophagy, and mitochondrial biogenesis while increasing ATP production without oxidative stress (1, 2, 3, 4, 5, 6)
T3 activates StAR, the rate-limiting-step of steroid hormone production (1, 2, 3)
Ep 75: Hormesis As An Anti-Scientific Defense For Industrial Pollution & Chemical Exposure (Part 1) (podcast episode)
Thyroid hormone activity is prokinetic (increases intestinal motility) and increases digestive enzyme and bile production, protecting against SIBO (1, 2, 3, 4, 5, 6, 7, 8) 
Ep. 74: Refuting Nutrition With Judy’s “Thoughts on the Ray Peat Diet” (Part 2) (podcast episode)
Rifaximin ineffectiveness for SIBO is associated with low androgenic activity and estrogen dominance (1)
Ep. 2: Gut and Digestion Part 1: Our Gut and Energy Balance (podcast episode)
Ep. 28: Restoring Gut Health, Why Not to Use Probiotics, and Ray Peat’s Carrot Salad (Q & A) (podcast episode)
Ep. 23: How to Slow Aging Part 1: Increasing Your Metabolism And Competing Theories (podcast episode)
Chris Masterjohn’s substack (website)