Ep. 93: How Cortisol Affects Your Mitochondria & Acute vs. Chronic Stress (Stress & Mitochondria Part 1)

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In this episode we discuss:

  • Why stress is not your friend 
  • The effects of cortisol on your mitochondria
  • Hans Selye’s general adaptation syndrome
  • How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism
  • Why acute stress does not lead to improved health via hormesis 

3:00 – an introduction to the paper: mitochondria as key components of the stress response 

4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance 

23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response

31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts 

34:04 – how long-term stress causes degeneration 

34:55 – functions of the mitochondria 

38:54 – mitochondria upregulate energy production in response to stress 

41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol) 

44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time 

50:30 – how mitochondria respond to excess stress and how this relates to fat gain 

59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism 

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